Biological and social models of depression that consider the consequences of depression on cognitive functioning, the hypothalamic pituitary adrenal (HPA) axis and immune function are discussed. To date, current treatments for MDD have limitations and treatments that target the co-morbidity of depression with medical illnesses, especially cardiovascular and metabolic diseases, are lacking. However, MDD is a leading cause of disability in the USA and worldwide. Patients with severe and persistent major depressive disorder (MDD) are typically medically healthy. What is Boondocks Festival in English.Wake-Up Blues: A Pathway for Therapeutic Developments for the Treatment of Depression.
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